Some drugs can activate AMPK, most prominently metformin, which is approved for diabetes and being trialed in dementia. Less well-known is aldometanib, developed by Lin’s team, which blocks aldolase, ...
The transcription factor sex-determining region Y-related high-mobility group-box gene 9 (SOX9) plays a critical role in organ development. Although ...
CR activates adenosine monophosphate (AMP)-activated protein kinase (AMPK), an enzyme that helps cells maintain energy balance. AMPK regulates several signalling pathways that delay aging ...
By enhancing the clearance of neutrophil extracellular traps (NETs) through the AMP-activated protein kinase (AMPK)/scavenger receptor A1 (SR-A1) pathway, this innovative approach could ...
CR turns on adenosine monophosphate (AMP)-activated protein kinase (AMPK), an enzyme that helps cells maintain energy balance. AMPK controls signaling pathways that postpone aging, including FOXO ...
Previous studies had demonstrated that mammals accumulate LCA during calorie restriction, activating a key molecule involved in metabolism called AMP-activated protein kinase (AMPK). According to ...