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28 天
CDK6:解锁白血病代谢重编程的关键,为克服耐药性提供新策略
为解决BCR::ABL1阳性白血病中CDK6高表达导致的代谢重编程及耐药问题,研究人员开展了一项关于CDK6在白血病细胞代谢调控中的作用机制研究。他们发现CDK6激酶活性对氧化磷酸化(OXPHOS)的调控至关重要,并揭示了其与NRF-1的竞争关系。研究表明,联合使用CDK4/6 ...
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