The adeno-associated viral (AAV) vectors have not been exploited extensively partly due to inability to generate high titer helper free recombinant viruses. Furthermore, the size of the transgene ...

To overcome these barriers, researchers explored lentiviral vectors, which integrate into the genome and bypass AAV-specific limitations. In the study, "Lentiviral Gene Therapy with CD34 ...

AAV vectors have a low immunogenicity profile, making them attractive for gene therapy applications. Lentiviruses are a subclass of retroviruses that can integrate their genetic material into the host ...

Viral vectors introduce genes and gene editing sequences into cells, and are a popular platform for gene therapy due to their safety and efficacy features. Adeno-associated viral (AAV) vectors in ...

Because they do not replicate without a helper virus, AAVs alone elicit low immune responses in mammalian cells. In addition, AAV vectors have high gene transfer efficiency, stable long-term ...

Vehicles such as lysophosphatidylcholine (LPC), EGTA, perfluorocarbon, or methylcellulose have been used to enhance gene transfer of Ad, AAV or lentiviral vectors. However, advancing these ...

More recently, the Vector Development Laboratory merged with our group, and we have expanded our services to offer AAV, first-generation adenovirus (FGAd), helper-dependent adenovirus (HDAd), ...