researchers add a unique pair of small barcodes consisting of a few nucleotides to the AAV sequence. Each viral genome also contains two flanking inverted terminal repeats (ITR) that enclose the ...

Previous efforts to circumvent the problem of the size limitation imposed by the AAV vector have focused ... candidate gene by deleting non-essential sequences, as well as using minimal promoters ...

He then used these recovered sequences to generate a second library for another round of testing. This pipeline resulted in several viral variants, but Deverman and his team decided to advance the ...

The researchers also showed that this approach worked well in identifying new sequences for the viral capsid of ...

IDT and Elegen partner to launch an early access program offering long, clonal gene synthesis and high-complexity genes up to ...

It increases the packing capacity for delivering normal copies of mutated genes whose coding sequence is greater in length than 4.5 kilobase pairs, the maximum capacity of one AAV. Delivering a ...