In 2014, researchers combined DNA barcoding with next-generation sequencing (NGS) to develop the adeno-associated virus (AAV) barcode-seq technology for streamlining ...

Gator Bio is the market’s sole solutions supplier that provides assays for genome titer and integrity, capsid titer, and empty-full ratio on a single automated platform. The AAV genome titer and ...

ddPCR technology then amplifies and detects the ligated oligo pairs, while an ITR-2 assay simultaneously detects the AAV genome. Software analyzes the signals from each capsid type to calculate ...

Potent in vivo gene editing in skeletal muscle of non-human primates by a novel, ultracompact CRISPR system delivered via a single AAV vector.

A new, streamlined AAV purification process that is both universal and scalable could ease commercialization constraint.

Single AAV Systems for HDR-Mediated Genome Editing in Vivo Dual AAV Systems for HDR-Mediated Genome Editing in Vivo ...

6 To generate a library of new capsids, Deverman edited a section of the AAV genome that contained a stretch of seven amino acids that he found can tolerate a bit of change but still form a capsid. By ...

Single AAV Systems for HDR-Mediated Genome Editing in Vivo Dual AAV Systems for HDR-Mediated Genome Editing in Vivo ...

The Vericheck ddPCR Empty-Full Capsid Kit was designed to help scientists and AAV developers accurately measure both the genome titer and empty-full ratios in their samples. In the world of AAV ...

To overcome these barriers, researchers explored lentiviral vectors, which integrate into the genome and bypass AAV-specific limitations. In the study, "Lentiviral Gene Therapy with CD34 ...